Fantasy Football Rankings Week 6, 2021: Proven model says start Darrel Williams, sit Dak Prescott

Chargers wide receiver Mike Williams enters Week 6 leading the NFL with six touchdown receptions, which has made him one of the most underrated 2021 Fantasy football picks. He didn't practice on Wednesday while nursing a knee injury, but if he suits up, Williams will get another opportunity to rack up points against the Baltimore Ravens, a defense that is giving up 296.4 passing yards per game. That means Williams could be near the top of the Week 6 Fantasy football rankings, but how does he stack up with fellow wideouts like Keenan Allen, Amari Cooper and Stefon Diggs given the injury?

Is Williams a lock to include in your Week 6 Fantasy football lineups? Which overlooked players should you incorporate into your Week 6 Fantasy football strategy? Before you lock in your lineups, be sure to check out the Week 6 Fantasy football rankings from the proven computer model at SportsLine. It can help you make those tough decisions on which players to start and which players to leave on the bench.

When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

Last week, the model was extremely high on Ravens wide receiver Marquise Brown, saying he'd finish as a top-10 player at his position. The result: Brown hauled in nine receptions for 125 yards and two touchdowns against the Colts. Anybody who had him in their lineup was well on their way to a huge week.

Now, the model, which simulates every NFL game 10,000 times, has revealed its Fantasy football rankings for Week 6 of the 2021 NFL season. Head to SportsLine now to see them.

Top Week 6 Fantasy football picks 

One player the model is extremely high on this week: Chiefs running back Darrel Williams. He is expected to see his usage increase dramatically after Clyde Edwards-Helaire suffered a sprained MCL against the Bills last week. Edwards-Helaire is now on IR, leaving Williams in line for a starting role in Kansas City's high-flying offense.

Williams finished with five carries for 27 yards and three receptions for 18 yards after taking over for Edwards-Helaire in the second half of Sunday's loss. Now, he'll be heavily involved against a Washington defense that has struggled mightily this season. In fact, Washington has given up five total touchdowns to running backs in its past two games. That's one of the main reasons why SportsLine's model ranks Williams as a top-20 running back this week, making him a rock-solid RB2.

And a massive shocker: Cowboys QB Dak Prescott, who's thrown three or more touchdown passes in each of his last three games, stumbles big-time and doesn't even crack the top 15 at his position. Prescott completed 68.8 percent of his passes for 302 yards and three touchdowns last week against the Giants

Prescott has already racked up 1,368 passing yards this season, but now he'll face-off against the Patriots, one of the NFL's stingiest defenses. The Patriots are giving up 317.6 yards per game on average to opposing offenses, which ranks fifth in the league. New England's defense also held Tom Brady, who leads the NFL in passing yards, to just 269 yards and zero touchdowns two weeks ago. With such a tough matchup on Sunday, Prescott is a player to consider putting on the bench in Week 6.

How to set your Week 6 Fantasy football rankings

The model is also calling for a surprising quarterback you aren't even thinking about to finish in the top 10 of its Fantasy football rankings. This pick could be the difference between winning big and going home with nothing. You can only see who it is here.

So who should you start and sit this week? And which surprising quarterback could lead you to victory? Visit SportsLine now to get Week 6 Fantasy football rankings for every position, plus see which QB is going to come out of nowhere to crack the top 10, all from the model that has out-performed experts big-time.